Trial Design

Innovation in
‍Clinical Trial Design

Discover how smarter, adaptive clinical trial design can accelerate development, reduce costs, and improve outcomes. Berry Consultants is a global leader in adaptive clinical trial design, leveraging Bayesian analysis and custom trial simulation to create more efficient, data-driven studies for drugs, biologics, and medical devices. From early-phase exploration to pivotal trials, our evidence-based approach supports better decisions at every stage.

Discover how smarter, adaptive clinical trial design can accelerate development, reduce costs, and improve outcomes. Berry is a global leader in adaptive clinical trial design, leveraging Bayesian analysis and custom trial simulation to create more efficient, data-driven studies for drugs, biologics, and medical devices. From early-phase exploration to pivotal trials, our evidence-based approach supports better decisions at every stage.

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Adaptive Trials

Design adaptive, forward-thinking trials that evolve as data emerges.

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Bayesian-Driven Insights

Leverage Bayesian analysis to make Innovative, data-driven decisions.

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Platform Trials

Custom trial designs and software built to solve your toughest challenges.

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FACTS (Fixed and Adaptive Clinical Trial Simulator) is the industry’s most powerful tool for designing, simulating, and analyzing adaptive clinical trials. With capabilities spanning from phase I dose escalation trials to adaptive platform trial designs - FACTS helps teams design custom trials to fit their unique clinical goals.

Designing the Future of Adaptive Clinical Trials

At Berry, we don’t just design clinical trials — we redefine them. Specializing in Bayesian trial design for drugs, medical devices, and biologics, our designs are almost always adaptive. Why? Because adaptive designs are smarter, more efficient, and more effective. Long before "adaptive" became an industry buzzword, we were pioneering these approaches alongside our clients to create trials that learn, evolve, and succeed.

Unlike routine statistical consulting, we focus on pushing the boundaries of trial design. Our work results in innovative, bespoke solutions that tackle the most complex challenges in clinical research. From exploratory early-phase studies to pivotal late-phase trials, we apply cutting-edge methodologies to get the most out of every stage in development.

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Bayesian Expertise with Real-World Impact

The foundation of our trial design expertise is Bayesian analysis. We specialize in Bayesian hierarchical models, meta-analysis, and decision analysis — critical tools for modern comparative effectiveness (CE) research. Bayesian methods bring flexibility and clarity to trial design, allowing for more precise decision-making at every step.

Creating and applying Bayesian priors is a key part of this process. Whether it’s modeling the perspectives of clinical teams, regulatory bodies, or payers, we have decades of experience in selecting, eliciting, and defending prior distributions in hundreds of clinical trial designs. Our team’s mastery of Bayesian methodologies ensures that every design decision is backed by a strong foundation of logic, probability, and transparency.

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Designing the Future of Adaptive Clinical Trials

Designing a trial on paper isn’t enough. True innovation happens when you can simulate the future. Berry is a leader in clinical trial simulation, giving teams the ability to "flight simulate" trial designs before they ever begin. Our FACTS simulation software is the most advanced tool on the market for exploring trial design, evaluating design efficiency, and justifying trial strategies to regulators.

Simulation transforms trial design from a guessing game into a data-driven decision process. It allows us to understand the likely outcomes of trial designs under a variety of conditions, ensuring that the design chosen is the best one possible. We’ve seen it time and time again: organizations that leverage simulation can accelerate development, reduce risk, and strengthen regulatory submissions.

Some problems require tools that don't exist yet — so we build them. Our ability to create custom software solutions is one of the reasons we’re uniquely equipped to handle the toughest challenges in trial design and analysis. Whether it’s automating a key aspect of design, running computationally heavy simulations, or creating entirely new design paradigms, we build the tools that modern clinical trials demand.

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Trial Implementation