The blog by Kert Viele discusses the potential biases in clinical trial results, particularly focusing on early stopping trials and the implications of only publishing successful outcomes, emphasizing that while biases exist, their significance varies based on the true response rate and the context of the trial.

In this video we look at designing Phase 2 Basket Trials where a treatment is explored in a large number of sub-groups (too many to be able to suitably power the trial in each sub-group).

In this video we look at designing seamless phase 2/3 trials, where a multi-arm phase 2 transitions when it can, selecting a dose and transitioning to a confirmatory phase 3.

In this video we look at designing response adaptive randomization (RAR) and arm dropping multi-arm phase 2 trials.

Join Dr. Cora Allen-Savietta from Berry Consultants on October 25 for a presentation on a platform trial in Parkinson's disease.

Joe Marion's blog discusses the challenges of designing phase I dose-finding studies in oncology using the Continual Reassessment Method (CRM) and Bayesian approaches, emphasizing the importance of selecting appropriate prior distributions to balance patient safety and effective dose escalation, while suggesting that re-parameterizing models can simplify the design process.