Other Videos, Webinars, and Podcasts

Podcast: Innovative Clinical Trial Design Identifies Effective Drug and Its Most Efficacious Dose for Treating Early Alzheimer Disease
In this September 6, 2024 episode by SciPod Health and Medicine, SciPod summarizes the recent paper “Lecanemab for Patients with Early Alzheimer Disease: Bayesian Analysis of a Phase 2b Dose-Finding Randomized Clinical Trial” by Dr. Donald Berry (Founder of Berry Consultants) and Scott Berry (President of Berry Consultants). In addition, the Podcast describes the benefit and success of adaptive clinical trial design within a Bayesian statistical approach not only within this Eisai Alzheimer trial, but many other trials. One example this Podcast highlights in another disease area, is the AWARD-5 trial for Eli Lilly’s type 2 diabetes drug Trulicity that has made it the most successful and profitable drug ever for Eli Lilly.

Podcast Series:  JAMAevidence – JAMA Guide to Statistics and Methods.
This Podcast series by JAMA provides valuable interviews about the statistical and methodological foundations of clinical research. A few notable episodes by Berry Consultants team members are:

• Bayesian Hierarchical Models with Dr. Anna McGlothlin (7/3/2024)
• Time-to-Event Analysis with Dr. Juliana Tolles (3/3/2023)
• Bayesian Analysis: Using Prior Information to Interpret the Results of Clinical Trials with Dr. Melanie Quintana (9/2/2021)
• Logistic Regression: What It Is and How to Use It in Clinical Research with Dr. William Meurer and Dr. Juliana Tolles (1/7/2021)
• Randomization in Clinical Trials with Dr. Roger Lewis (12/3/2020)
• Minimal Clinically Important Difference: Defining What Really Matters to Patients with Dr. Anna McGlothlin (8/6/2020)
• JAMA Guide to Statistics and Methods with Dr. Roger Lewis (12/5/2019)
• Bayes for Clinicians Who Need to Know but Don’t Like Math with Dr. Anna McGlothlin (12/11/2018)

In the fall of 2023, webinar sessions on “Introduction to Adaptive Trial Designs using FACTS” were held. Each session covered the design of a different type of trial and are listed below.

Phase 1 Dose Escalation, October 5, 2023
Click here for the recorded webinar
Click here for the presentation slides (PDF)

Group Sequential Designs, October 12, 2023
Click here for the recorded webinar
Click here for the presentation slides (PDF)

Phase 2 Arm Dropping and RAR, October 19
Click here for the recorded webinar
Click here for the presentation slides (PDF)

Seamless Phase 2/3 Trials, October 26, 2023
Click here for the recorded webinar
Click here for the presentation slides (PDF)

Basket Trials, November 2, 2023
Click here for the recorded webinar
Click here for the presentation slides (PDF)

Platform Trials & MAMS designs, November 9, 2023
Click here for the recorded webinar
Click here for the presentation slides (PDF)  

The Implementation of Platform Trials for ALS Research
Dr. Melanie Quintana, statistical scientist and director at Berry Consultants, discussed innovative clinical trial design in ALS research at the 2023 MDA conference.

Adaptive Platform Clinical Trials: Application to ILD
Roger J. Lewis, MD, PhD, lectured on REMAP-ILD at HCOR scientific meeting (Sao Paulo, Brazil).

ANA Highlights Statistical Snapshots Adaptive Designs
Dr. Scott Berry of Berry Consultants presented in the Statistical Snapshots Series: “Adaptive Trial Designs.”

EU-PEARL Webinar – Non-Concurrent Controls in Platform Trials                                                Dr. Scott Berry and Dr. Kert Viele of Berry Consultants presented in the EU-PEARL webinar on February 24.

Global Coalition for Adaptive Research released a series of Spotlight short videos presented by Don Berry on the GBM AGILE Trial.

• A Brief History of GBM AGILE
• How does GBM AGILE work?
• How is GBM AGILE paving the way for more innovative research?
• What makes GBM AGILE an innovative trial?
• Bringing Bayesian Statistics into Clinical Trials

PodCast: Bayesian Analysis, Using Prior Information
Roger J. Lewis, MD, PhD, discussed Bayesian Analysis: Using Prior Information to Interpret the Results of Clinical Trials with Melanie Quintana, PhD.

The PRINCIPLE Adaptive Platform Trial for Community Treatment of COVID-19: Innovation in Trial Design and Delivery
Dr. Ben Saville of Berry Consultants and Dr. Chris Butler of Oxford University present a Grand Rounds session on the PRINCIPLE Adaptive Platform Trial.

HEALEY ALS Platform Trial Launch Announcement
Learn more about this groundbreaking trial designed by Berry Consultants to accelerate the development of effective treatments for people in ALS. Weekly updates and additional videos can be found on HEALEY ALS Platform Trial Video Library of Mass General Hospital.

PREPARE (Platform for European Preparedness Against (Re-)emerging Epidemics) releases a series of webinars.

• Why Future Clinical Trials will be Platform Trials (with Scott Berry at the 20:50 mark on “Taming the Beast”).
• Complete PREPARE Video Library

REMAP-CAP (Randomized, Embedded, Multifactorial Adaptive Platform trial for Community-Acquired Pneumonia) releases a series of videos:

• Scott Berry – REMAP-CAP Current State Statistical Model
• Sit Down with Lindsay Berry
• Complete REMAP-CAP Video Library

Introducing Decision-Making Under Uncertainty to Medical Research: Designing More Efficient and More Accurate Clinical Trials
Don Berry’s presentation at the Simons Institute for the Theory of Computing at University of California Berkeley.

The Lowdown on Adaptive Clinical Trials with Don Berry
Mendelspod.com interviews Don Berry through a podcast sponsored by the National Biomarker Development Alliance (NBDA) on July 28, 2014 that discusses a promising new approach to clinical trials.

President’s Council of Advisors on Science and Technology (PCAST)
Don Berry presents as part of a panel of Researchers on the topic of “Improving Scientific Reproducibility in an Age of International Competition and Big Data I” at the PCAST Public Meeting on January 31, 2014.

The Design of Complex Adaptive Trials
Scott Berry presents at the “Transforming Drug Development – Delivering Innovation and Efficiency through Adaptive Clinical Trials” conference that was co-sponsored by Berry Consultants.

A Fully Bayesian World: What a Wonderful World
Scott Berry presents at the Royal Statistical Society’s, “PSI Debate: This house believes that pharmaceutical drug development and regulation should become fully Bayesian”.

Slowly but surely, Bayesian Ideas revolutionize medical research
Don Berry at the 2012 International Society for Bayesian Analysis (ISBA) World Meeting in Kyoto, Japan.

The Biomarkers Consortium: I-SPY 2 Press Conference
Don Berry speaks as part of the press conference for I-SPY 2, an innovative breast cancer clinical trial.